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tert-Butyl Alcohol (tBA) is used as a solvent as a denaturant for ethanol and several other alcohols in the manufacture of flotation agents, fruit essences, and perfumes as an octane booster in gasoline as a dehydrating agent and as a chemical intermediate in the manufacture of methyl methacrylate.
While water is the solvent of choice for the lyophilization of pharmaceuticals, tert-butyl alcohol (TBA) along with water can confer several advantages including increased solubility of hydrophobic drugs, decreased drying time, improved product stability and reconstitution characteristics. The goal of this work was to generate the phase diagram and determine the eutectic temperature and composition in the “water rich” region (0.0 to 25.0% w/w TBA) of TBA–water mixtures. Solutions of different compositions were frozen and characterized by low temperature differential scanning calorimetry and powder X-ray diffractometry (XRD).
tert-Butyl Alcohol is a colorless liquid or crystalline solid with a mothball-like odor. It is used in making flavors and perfumes, as a solvent for pharmaceuticals, a paint remover, and as an additive in unleaded gasoline.