Title
ETHYL OLEATE FOR SYNTHESIS 98%
SKU
RXSOL-60-6604-568
Supply Location::
Category
Lab Chemical-60
SHORT DESCRIPTION:::
PRODUCT REMARK:::>
TAG IDENFIFICATION:::
FIELD NOTE:::
Ethyl oleate uses Ethyl oleate is used as a solvent for pharmaceutical drug preparations involving lipophilic substances such as steroids. It also finds use as a lubricant and a plasticizer.
Note
- The ethyl oleate used by the submitters was prepared by esterification of commercial U.S.P. grade oleic acid and fractionated through a Widmer column. The fraction boiling at 160–170°/1 mm., nD25 1.4482–1.4570, iodine value 83.6 (calculated 81.8), was used.
- The purity of the absolute ethanol is of prime importance. Ethanol dried only by a lime process gives a low yield (20–25%). The ethanol used in this procedure was dried over lime and then over aluminum tert-butoxide, after which it was distilled directly into the flask used for the reaction.
- The submitters used a modified Widmer column; the checkers, a Claisen flask modified with a short Vigreux column.
Application
- E 1625 (OTTO) Ethyl oleate, 99% Cas 111-62-6 - used to prepare the oily phase of self-microemulsifying drug delivery system (SMEDDS) for tacrolimus (Tac).
